| Annotated protein: | Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4]. Gene symbol: GPC4. Taxonomy: Mus musculus (Mouse). Uniprot ID: P51655 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GPC4 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | de Wit J, et al. "Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development" Neuron. 2013 Aug 21;79(4):696-711 PMID:23911103 |
| Figure(s): | fig 4 |
| Annotation description: | Myc-LRRTM4 induces clustering of endogenous GPC4 in coculture assays. HA-GPC4 expressed in 293T cells induces clustering of the excitatory postsynaptic marker PSD-95 but not of the inhibitory postsynaptic marker gephyrin in coculture assays. HA-GPC4-mediated clustering of endogenous LRRTM4 in contacting dendrites requires GAG chains in coculture assays. 21/2/2018 Pim - Abstract: "Glypican binds LRRTM4, but not LRRTM2, in an HS-dependent manner. Glypican 4 (GPC4) and LRRTM4 localize to the pre- and postsynaptic membranes of excitatory synapses, respectively. Consistent with a trans-synaptic interaction, LRRTM4 triggers GPC4 clustering in contacting axons and GPC4 induces clustering of LRRTM4 in contacting dendrites in an HS-dependent manner. " |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2451 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |