| Annotated protein: | receptor protein-tyrosine kinase (EC 2.7.10.1). Gene symbol: EPHA4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZZK3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EPHA4 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse disassembly (GO:1905806) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Fu WY, et al. "Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism" Nat Neurosci. 2007 Jan;10(1):67-76 PMID:17143272 |
| Figure(s): | Fig 1, 5, 7 |
| Annotation description: | Fig.1: "Inhibition of Cdk5 activity attenuates the ephrin-A1-stimulated dendritic spine retraction of pyramidal neurons in organotypic hippocampal slices" - "Ephrin-A1 reduced the spine density in pSUPER and pSUPER-C42 RNAi-transfected neurons, but it did not reduce the spine density in EphA4-knockdown neurons (Fig. 1d,e)." Fig.5: "Cdk5 activity regulates ephrin-A1-stimulated EphA4 activation and RhoA activity in neurons" Fig.7: "Cdk5 phosphorylation of ephexin1 regulates EphA4-dependent GEF activity" |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal Western blot |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 2449 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |