| Annotated protein: | Metabotropic glutamate receptor 7 (mGluR7). Gene symbol: GRM7. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q68ED2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRM7 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | cerebellum, glutamatergic |
| Annotated paper: | Perroy J, et al. "PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7" EMBO J. 2002 Jun 17;21(12):2990-9 PMID:12065412 |
| Figure(s): | Fig4 |
| Annotation description: | pharmacological inhibition of mGlur7 results in changes in spontaneous miniature synaptic events, which strongly implies a presynaptic regulation. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 2425 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |