| Annotated protein: | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit). Gene symbol: CDK5. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q03114 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CDK5 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse disassembly (GO:1905806) |
| Synapse type(s): | hippocampus, glutamatergic Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Fu WY, et al. "Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism" Nat Neurosci. 2007 Jan;10(1):67-76 PMID:17143272 |
| Figure(s): | Fig 1, Fig3 d,e,f |
| Annotation description: | loss of CDK5 (by pharmacological and RNAi means) interferes with the ability of an axon guidance molecule (ephrin) to cause spine retraction. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 2423 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |