| Annotated protein: | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit). Gene symbol: CDK5. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q03114 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CDK5 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Fu AK, et al. "Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction" Nat Neurosci. 2001 Apr;4(4):374-81 PMID:11276227 |
| Figure(s): | Fig. 2A |
| Annotation description: | Immunofluorescence of rat neuromuscular junctions shows that CDK5 is colocalized with postsynaptic acetylcholine receptors. 9/2/2018 Pim - The data in Fig.2 do not resolve the postsynapse from other synaptic compartments. In order to reach this conclusion the authors integrate gene expression and functional data on CDK5 regulating nAChR expression in myotubes. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 2422 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |