| Annotated protein: | Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2). Gene symbol: CACNB2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8CC27 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CACNB2 |
| Ontology domain: | Biological Process |
| SynGO term: | voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (GO:0099626) |
| Synapse type(s): | retina Photoreceptor ribbon synapse |
| Annotated paper: | Ball SL, et al. "Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer" Invest Ophthalmol Vis Sci. 2002 May;43(5):1595-603 PMID:11980879 |
| Figure(s): | Fig 3A |
| Annotation description: | Electroretinogram recordings show that mice lacking the beta2 subunit of calcium channels have severe deficits in light responses associated with synaptic transmission from photoreceptor to bipolar cells for both cones and rods. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electrophysiology (generic) |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 2420 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |