Annotated protein:	Voltage-dependent R-type calcium channel subunit alpha-1E (BII) (Brain calcium channel II) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (RBE-II) (RBE2) (Voltage-gated calcium channel subunit alpha Cav2.3). Gene symbol: CACNA1E. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q07652
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SynGO gene info:	SynGO data @ CACNA1E
Ontology domain:	Biological Process
SynGO term:	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (GO:0099626)
Synapse type(s):	thalamus, GABAergic
Annotated paper:	Joksovic PM, et al. "Isoflurane-sensitive presynaptic R-type calcium channels contribute to inhibitory synaptic transmission in the rat thalamus" J Neurosci. 2009 Feb 4;29(5):1434-45 PMID:19193890
Figure(s):	Fig6A,B
Annotation description:	Use of a well-documented specific blocker of this type of voltage gated calcium channel reduces evoked inhibitory postsynaptic currents and increased paired pulse ratios, implying a presynaptic origin. 8/2/2018 Pim - The effect on Ca2+ is not shown directly in these experiments. However, CACNA1E is a known VGCC. The presynaptic action of CACNA1E inhibitor on ca2+-dependent SV release implies that CACNA1E is involved in 'voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (GO:0099626)'.
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Antagonist / agonist
Evidence tracking, Experiment Assay:	Whole-cell patch clamp
Annotator(s):	Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548)
Lab:	Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA
SynGO annotation ID:	2419
Dataset release (version):	20231201
View annotation as GO-CAM model: