| Annotated protein: | Actin-related protein 3 (Actin-like protein 3). Gene symbol: ACTR3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q4V7C7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ACTR3 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic actin cytoskeleton organization (GO:0098974) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Wegner AM, et al. "N-wasp and the arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses" J Biol Chem. 2008 Jun 6;283(23):15912-20 PMID:18430734 |
| Figure(s): | Fig6A<B<C |
| Annotation description: | Knockdown of ARP2/3 results in a lower spine density. 8/2/2018 Pim - Data looks at cocalization of PSD95 and SV2 spots as a readout for synapse formation. Authors show that ACTR3 is located at the postsynaptic side. ACTR3 is a known actin remodeling protein part of the Arp2/3 complex. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 2417 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |