Annotated protein:Actin-related protein 3 (Actin-like protein 3). Gene symbol: ACTR3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q4V7C7
antibody wiki:
SynGO gene info:SynGO data @ ACTR3
Ontology domain:Biological Process
SynGO term:postsynaptic actin cytoskeleton organization (GO:0098974)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Wegner AM, et al. "N-wasp and the arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses" J Biol Chem. 2008 Jun 6;283(23):15912-20 PMID:18430734
Figure(s):Fig6A<B<C
Annotation description:Knockdown of ARP2/3 results in a lower spine density.

8/2/2018 Pim
- Data looks at cocalization of PSD95 and SV2 spots as a readout for synapse formation. Authors show that ACTR3 is located at the postsynaptic side. ACTR3 is a known actin remodeling protein part of the Arp2/3 complex.
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:RNAi / shRNA
Evidence tracking, Experiment Assay:Wide-field fluorescence
Annotator(s):Ryan J. Farrell (ORCID:0000-0003-4022-8707)
Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826)
Camila Pulido (ORCID:0000-0002-5648-066X)
Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623)
Timothy Ryan (ORCID:0000-0003-2533-9548)
Lab:Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA
SynGO annotation ID:2417
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology