| Annotated protein: | Tuberin (Tuberous sclerosis 2 protein). Gene symbol: TSC2. Taxonomy: Homo sapiens (Human). Uniprot ID: P49815 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TSC2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | brain cerebral cortex |
| Annotated paper: | Focking M, et al. "Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder" Transl Psychiatry. 2016 Nov 29;6(11):e959 PMID:27898073 |
| Figure(s): | Supplementary Table 2 |
| Annotation description: | Thirty-six subjects pooled into 18 samples (8 pairs bipolar disorder and 10 pairs of control) were studied (Table 1). A total of 2867 proteins were identified by tandem mass spectrometry (Q-Exactive) after data input to the MaxQuant bioinformatics software (Max-Planck Institute for Biochemistry, Munich, Germany). Proteins were excluded if they were detected in less than 50% of samples from each group, leaving 2033 proteins for inclusion in the final statistical analysis (Supplementary Table 2). Six hundred twenty proteins were differentially expressed in bipolar disorder compared with controls (P≤0.05). Two hundred eighty-eight proteins were found to be significantly differentially expressed after correcting for multiple testing with FDR<0.05 (Supplementary Table 2 and Supplementary Figure 1). Rheb is not in the deferentially expressed proteins between the different groups but it was detected in the MS data. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | none of the above |
| Evidence tracking, Experiment Assay: | Mass-spectrometry Biochemical fractionation (generic) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 2416 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |