| Annotated protein: | Protein TANC1 (TPR domain, ankyrin-repeat and coiled-coil domain-containing protein 1). Gene symbol: TANC1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q6F6B3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TANC1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse organization (GO:0099175) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Han S, et al. "Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins" J Neurosci. 2010 Nov 10;30(45):15102-12 PMID:21068316 |
| Figure(s): | fig 3, 7 |
| Annotation description: | TANC overexpression in cultured neurons increases the density of dendritic spines and excitatory synapses. Selective decrease in spine density in the CA3 region of the TANC1-/- hippocampus. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2410 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |