| Annotated protein: | Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta). Gene symbol: DGKZ. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q80UP3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DGKZ |
| Ontology domain: | Biological Process |
| SynGO term: | maintenance of postsynaptic density structure (GO:0099562) |
| Synapse type(s): | hippocampus, glutamatergic Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Kim K, et al. "Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance" EMBO J. 2009 Apr 22;28(8):1170-9 PMID:19229292 |
| Figure(s): | fig 4, 5, 6, 7 |
| Annotation description: | Knockdown of DGKZ decreases spine density. Reduced PA production and spine density in DGKZ KO mice. Reduced excitatory synaptic transmission in DGKZ KO mice. Knockdown of DGKZ affects the maintenance but not formation of dendritic spines. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp Western blot |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2402 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |