| Annotated protein: | Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107). Gene symbol: DGKI. Taxonomy: Mus musculus (Mouse). Uniprot ID: S4R215 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DGKI |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | hippocampus, glutamatergic Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Yang J, et al. "DGKiota regulates presynaptic release during mGluR-dependent LTD" EMBO J. 2011 Jan 5;30(1):165-80 PMID:21119615 |
| Figure(s): | fig 5 |
| Annotation description: | Figure 5 suggest that DGKι deficiency has a small effect on presynaptic release, with changes occurring at earlier developmental stages (2-5 weeks) and at particular inter-stimulus intervals. This increase in presynaptic release, although small, may partly contribute to the increase in synaptic transmission indicated in the input-output curve. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2401 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |