| Annotated protein: | Neuroplastin (Glycoprotein 55/65) (gp55/65) (Stromal cell-derived receptor 1) (SDR-1). Gene symbol: NPTN. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P97546 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NPTN |
| Ontology domain: | Biological Process |
| SynGO term: | trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission (GO:0099557) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Smalla KH, et al. "The synaptic glycoprotein neuroplastin is involved in long-term potentiation at hippocampal CA1 synapses" Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4327-32 PMID:10759566 |
| Figure(s): | fig. 4 and 5, table 1 |
| Annotation description: | Antibodies against np65 and recombinant neuroplastin extracellular domains prevent maintenance of LTP at CA1 synapses in hippocampal slices (fig. 4, table 1). Homophilic interaction in trans is shown in heterologous cells (fig. 5) 67/12/2016 Pim: - Figure 5 shows trans-interaction between recombinant np65/55 proteins in homophilic aggregation assay with microspheres. This would support a inference to pre-2-post-synapse adhesion when combined with evidence on localization to "presynaptic membrane" and "postsynaptic membrane". - regulation of synaptic transmission is shown with LTP experiments (Fig.4). A "signaling" role that underlies the effect of NP interference is **inferred** from the established role NP initiating intracellular signaling cascades in the synapse (PMID:25040546 - Review describing potential signaling pathways in transsynaptic signaling via NPs) |
| Evidence tracking, Biological System: | Intact tissue Cell-free system |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | A "signaling" role that underlies the effect of NP interference is **inferred** from the established role NP initiating intracellular signaling cascades in the synapse (PMID:25040546 - Review describing potential signaling pathways in transsynaptic signaling via NPs) @ PMID:25040546 |
| SynGO annotation ID: | 24 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |