| Annotated protein: | Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (GluA1). Gene symbol: GRIA1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P23818 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIA1 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Mack V, et al. "Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice" Science. 2001 Jun 29;292(5526):2501-4 PMID:11431570 |
| Figure(s): | Fig.3 |
| Annotation description: | Fig.3: "Recovery of SC/CA1 LTP inGFPGluR-A-expressing GluR-A-/- mice" Mice defective in the AMPAR subunit GRIA1; GluR1 do not show the phenomenon of hippocampal LTP which is known to be caused by AMPARs moving into the PSD. Reexpression of GFP-Glur1 can rescue this defect. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2387 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |