| Annotated protein: | Glutamate receptor ionotropic, NMDA 2D (GluN2D) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D). Gene symbol: GRIN2D. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62645 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIN2D |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Harney SC, et al. "Extrasynaptic NR2D-containing NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs" J Neurosci. 2008 Nov 5;28(45):11685-94 PMID:18987204 |
| Figure(s): | Fig.4 |
| Annotation description: | GRIN2D is a well known component of NMDARs. Via PPDA sensitivity NR2D-containing NMDARs are shown to act as extrasynaptic spillover receptors, that move into the PSD upon induction of LTP. - PPDA is proposed as a specific inhibitor of NR2D-containing NMDARs |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2385 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |