| Annotated protein: | Protocadherin-8 (Activity-regulated cadherin-like protein) (Arcadlin). Gene symbol: PCDH8. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZE55 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PCDH8 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Yamagata K, et al. "Arcadlin is a neural activity-regulated cadherin involved in long term potentiation" J Biol Chem. 1999 Jul 2;274(27):19473-1979 PMID:10383464 |
| Figure(s): | Fig.7 |
| Annotation description: | Fig.7: "Arcadlin Antibody Suppresses Synaptic Transmission and Blocks LTP" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2368 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |