| Annotated protein: | Protocadherin-8 (Activity-regulated cadherin-like protein) (Arcadlin). Gene symbol: PCDH8. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZE55 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PCDH8 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synaptic membrane adhesion (GO:0099179) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Yasuda S, et al. "Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases" Neuron. 2007 Nov 8;56(3):456-71 PMID:17988630 |
| Figure(s): | Fig.2, 3, 5, 7 |
| Annotation description: | Fig.2: "Arcadlin Inhibits the Adhesive Activity of N-Cadherin" Fig.3: "Depolarization or Elevated cAMP Level Increases N-Cadherin Internalization through an Arcadlin-Dependent Pathway" Fig.5: "Homophilic Interaction of Arcadlin Causes Internalization via the Activation of Arcadlin-TAO2β-p38 MAPK Signaling Pathway" Fig.7: "The Arcadlin-TAO2β-p38 MAPK Pathway Mediates the Internalization of N-Cadherin" [Fig.8: "The Effects of Arcadlin on Dendritic Spine Density"] N-Cadherin is a well established mediator of pre/post-synaptic adhesion. In this paper Arcadlin; PCDH8 is shown to not mediate adhesion itself, but to regulate the activity dependent internalization of N-cadherin, thereby affecting synapse organization (this paper) and synaptic transmission (see pmid:10383464). |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Microscopy (generic) |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Initial paper on the discovery of Arcadlin; PCDH8. Postulates this protein is an cell-adhesion protein that modulates LTP. The primary paper in this ticket (pmid:10383464) shows Arcadlin; PCDH8 itself has weak adhesive properties, and appears to act as a negative regulator of cell-cell-adhesion mediated by N-cadherin. @ PMID:10383464 |
| SynGO annotation ID: | 2367 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |