| Annotated protein: | Protocadherin-8 (Activity-regulated cadherin-like protein) (Arcadlin). Gene symbol: PCDH8. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZE55 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PCDH8 |
| Ontology domain: | Cellular Component |
| SynGO term: | synapse (GO:0045202) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Yamagata K, et al. "Arcadlin is a neural activity-regulated cadherin involved in long term potentiation" J Biol Chem. 1999 Jul 2;274(27):19473-1979 PMID:10383464 |
| Figure(s): | Fig.6 |
| Annotation description: | Fig.6: "Regulation and synaptic localization of Arcadlin protein" Literal: "Arcadlin is naturally expressed in hippocampal neurons and localized at both soma and synapses in association with the marker synaptophysin." The protein seems postsynaptic based on report of dendritic localization, but I chose the safer term 'synapse (GO:0045202)'. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2366 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |