| Annotated protein: | Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (Synaptic adhesion-like molecule 4). Gene symbol: LRFN3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: B0BNK7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRFN3 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of presynapse assembly (GO:1905606) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lie E, et al. "SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion" Nat Commun. 2016 Aug 2;7:12328 PMID:27480238 |
| Figure(s): | fig 4, 6, 7 |
| Annotation description: | Fig.4: "SALM4 cis-interacts with SALMs 2/3/5." Fig.6: "SALM4 inhibits SALM2-dependent excitatory synapse facilitation and SALM3/5-dependent presynaptic differentiation." Fig.7: "SALM4 inhibits the interaction between SALM3/5 and LAR." Literal from abstract: "These results suggest that SALM4 negatively regulates excitatory synapses via cis inhibition of the trans-synaptic SALM3-LAR adhesion." |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp IP + WB/MSMS |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2364 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |