| Annotated protein: | Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6). Gene symbol: SLC6A6. Taxonomy: Mus musculus (Mouse). Uniprot ID: O35316 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLC6A6 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, GABAergic |
| Annotated paper: | Sergeeva OA, et al. "Taurine-induced long-lasting enhancement of synaptic transmission in mice: role of transporters" J Physiol. 2003 Aug 1;550(Pt 3):911-9 PMID:12824447 |
| Figure(s): | Fig.3 |
| Annotation description: | The taurine transporter transports taurine into neurons. Taurine transporter (TAUT) KO mice exhibit a strong reduction in the taurine concentration in different brain regions (Table 2). Taurine levels were determined from microdissected, homogenized tissue samples using an amino acid analyser. 25/01/2018 Pim - Taurine is a modulator of LTP (Fig.1+2). KO of the taurine transporter strengthens this effect. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 2361 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |