| Annotated protein: | Catenin delta 1. Gene symbol: CTNND1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZZZ9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CTNND1 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic active zone cytoplasmic component (GO:0098831) |
| Synapse type(s): | hippocampus, glutamatergic cerebellum, glutamatergic Schaffer collateral synapse (CA3->CA1) Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Chauvet N, et al. "Distribution of p120 catenin during rat brain development: potential role in regulation of cadherin-mediated adhesion and actin cytoskeleton organization" Mol Cell Neurosci. 2003 Apr;22(4):467-86 PMID:12727444 |
| Figure(s): | Figure 8, 9A, B |
| Annotation description: | Electron microscopy of the CA1 and CA3 regions using peroxidase-based staining of catenin delta/p120catenin, indicates expression in the presynaptic compartment, associated with the active zone region. Antibody info: 'Two monoclonal anti- bodies (mAbs) raised against p120ctn were used. mAb pp120 has been raised against p120ctn carboxyl-terminal amino acids 790-911 and recognizes all known p120ctn isoforms. mAb 6H11 was raised against the amino-terminal region of p120ctn, amino acids 8-349, and recognizes spe- cifically isoforms 1 and 2 of p120ctn'. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 2360 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |