Annotated protein:protein-tyrosine-phosphatase (EC 3.1.3.48). Gene symbol: PTPRD. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: M0RB22
antibody wiki:
SynGO gene info:SynGO data @ PTPRD
Ontology domain:Biological Process
SynGO term:regulation of postsynaptic density assembly (GO:0099151)
Synapse type(s):retina, glutamatergic
Annotated paper:Farhy-Tselnicker I, et al. "Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation" Neuron. 2017 Oct 11;96(2):428-445.e13 PMID:29024665
Figure(s):Fig.3, 4
Annotation description:Fig.3: "Glypican 4 Acts through Presynaptic RPTPs to Increase Synapse Formation"
Fig.4: "Glypican 4 Acts through Presynaptic RPTPs to Induce the Release of NP1 and to Cluster GluA1 AMPA Receptors"
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Antagonist / agonist
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2356
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology