| Annotated protein: | protein-tyrosine-phosphatase (EC 3.1.3.48). Gene symbol: PTPRD. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: M0RB22 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRD |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic density assembly (GO:0099151) |
| Synapse type(s): | retina, glutamatergic |
| Annotated paper: | Farhy-Tselnicker I, et al. "Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation" Neuron. 2017 Oct 11;96(2):428-445.e13 PMID:29024665 |
| Figure(s): | Fig.3, 4 |
| Annotation description: | Fig.3: "Glypican 4 Acts through Presynaptic RPTPs to Increase Synapse Formation" Fig.4: "Glypican 4 Acts through Presynaptic RPTPs to Induce the Release of NP1 and to Cluster GluA1 AMPA Receptors" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2356 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |