| Annotated protein: | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) (SEZ-2). Gene symbol: YWHAZ. Taxonomy: Mus musculus (Mouse). Uniprot ID: P63101 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ YWHAZ |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic target recognition (GO:0008039) |
| Synapse type(s): | Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Cheah PS, et al. "Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3zeta deficiency" Mol Psychiatry. 2012 Apr;17(4):451-66 PMID:22124272 |
| Figure(s): | fig 6 |
| Annotation description: | From Results section: "In 14-3-3ζ062-/- mice, misrouted axons also formed aberrant synapses within the stratum pyramidale (Figure 6). Visualization of synaptic boutons by golgi stain further revealed notable differences in synapse formation in CA3. In control animals, large spine excrescences on the proximal region of the apical dendrites were followed by fine-calibre dendritic branches. In pyramidal neurons of 14-3-3ζ062-/- mice, the dendritic tree appeared to have similar numbers of branch points but had thorny excrescences from the misrouted mossy fibre tracts on both proximal and distal apical dendrites of all mice examined." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection) |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence Microscopy (generic) |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 2352 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |