Annotated protein:	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (38 kDa BFA-dependent ADP-ribosylation substrate) (BARS-38) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-). Gene symbol: GAPDH. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P04797
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SynGO gene info:	SynGO data @ GAPDH
Ontology domain:	Cellular Component
SynGO term:	postsynaptic density, intracellular component (GO:0099092)
Synapse type(s):	neocortex, glutamatergic
Annotated paper:	Wu K, et al. "The synthesis of ATP by glycolytic enzymes in the postsynaptic density and the effect of endogenously generated nitric oxide" Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13273-8 PMID:9371836
Figure(s):	Figure 1
Annotation description:	Results section: "Immunostaining of G3PD in Brain Slice" - Literal:"As many as 66% of all morphologically identifiable synapses with well-defined PSDs exhibited immunoreactivity, including symmetric and asymmetric synapses and those with perforated PSDs." Figure 1 Legend: - Literal: "The G3PD antibody was diluted 1:2,000. T marks unlabeled terminals whereas arrowheads mark immunoreactive PSD at a dendritic spine." Discussion, 3rd paragrah : -Literal: "Our finding of G3PD*, PGK, LDH, aldolase, and possibly other glycolytic enzymes in the PSD suggests there exists at the PSD level a rather complete glycolytic complex for the generation of ATP". *G3PD = GAPDH
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Antibody (detection)
Evidence tracking, Experiment Assay:	Electron Microscopy
Annotator(s):	Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306)
Lab:	Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra
SynGO annotation ID:	2347
Dataset release (version):	20231201
View annotation as GO-CAM model: