Annotated protein:Protein shisa-7 (Cystine-knot AMPAR modulating protein of 59 kDa) (CKAMP59) (GABA(A) receptor auxiliary subunit Shisa7) (Shisa family member 7). Gene symbol: SHISA7. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8C3Q5
antibody wiki:
SynGO gene info:SynGO data @ SHISA7
Ontology domain:Biological Process
SynGO term:regulation of postsynaptic neurotransmitter receptor activity (GO:0098962)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Schmitz LJM, et al. "The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory" Elife. 2017 Dec 4;6:e24192 PMID:29199957
Figure(s):fig 1,2,3,6
Annotation description:Figure 1; Shisa7 is a type-I transmembrane protein interacting with AMPA-type receptors
Figure 2; Shisa7 effects on AMPAR desensitization rate and recovery from desensitization
Figure 3; Shisa7 prolongs synaptic AMPAR currents
Figure 6; Deletion of Shisa7 slows down initiation and decreases maintenance of LTP

Both analyses compare Shisa7 KO mice to WT littermates
Evidence tracking, Biological System:Intact tissue
Non-neuronal tissue
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Over-expression
Evidence tracking, Experiment Assay:Whole-cell patch clamp
Field recordings
IP + WB/MSMS
Annotator(s):Frank Koopmans (ORCID:0000-0002-4973-5732)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2345
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology