| Annotated protein: | Protein shisa-6 (Cystine-knot AMPAR modulating protein of 52 kDa) (CKAMP52) (Shisa family member 6). Gene symbol: SHISA6. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q3UH99 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SHISA6 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic neurotransmitter receptor diffusion trapping (GO:0098970) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Klaassen RV, et al. "Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity" Nat Commun. 2016 Mar 2;7:10682 PMID:26931375 |
| Figure(s): | fig 3, 4 |
| Annotation description: | Shisa6 interacts with Dlg4/PSD95 in (fig 3, hippocampal neurons, FRET) and decreases AMPAR mobility through its PDZ-binding domain (fig 4, hippocampal neurons, Single-nanoparticle tracking of surface AMPARs). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Microscopy (generic) FRET |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2343 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |