| Annotated protein: | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1). Gene symbol: YWHAZ. Taxonomy: Homo sapiens (Human). Uniprot ID: P63104 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ YWHAZ |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse maturation (GO:0090128) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Angrand PO, et al. "Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling" Mol Cell Proteomics. 2006 Dec;5(12):2211-27 PMID:16959763 |
| Figure(s): | fig 6 |
| Annotation description: | "Interestingly expression of YFP-14-3-3z in hippocampal neurons had a dramatic effect on spine formation. 14-3-3z-overexpressing neurons presented a particularly high number of mature spines with mushroom-like heads, covering in some cases the entire dendrite (Fig. 6, B, E, and F). The presence of 14-3-3z increased the density of mature spines by 40% compared with control YFP-transfected neurons (Fig. 6F)." "Co-transfection of 14-3-3z with PIX did not change the total number of protrusions in the dendrites (Fig. 6E) but increased significantly the number of protrusions with heads in comparison to PIX alone (see arrows in Fig. 6D and quantification in Fig. 6, E and F) suggesting that 14-3-3 is a potent spine maturation regulator. The protrusions in the double 14-3-3z- and PIX-transfected neurons had mature heads independent of the length of the protrusion." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 2341 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |