| Annotated protein: | Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Leukocyte common antigen-related protein-tyrosine phosphatase 2) (LAR-PTP2) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma). Gene symbol: PTPRS. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q64605 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRS |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic density assembly (GO:0099151) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Takahashi H, et al. "Postsynaptic TrkC and presynaptic PTPsigma function as a bidirectional excitatory synaptic organizing complex" Neuron. 2011 Jan 27;69(2):287-303 PMID:21262467 |
| Figure(s): | Fig 4, 5, 6 |
| Annotation description: | Fig.4: "TrkC and PTPσ Ectodomains Induce Excitatory Presynaptic and Postsynaptic Differentiation, Respectively" Fig.5: "Aggregation of TrkC or PTPσ on the Neuron Surface Mediates Postsynaptic and Presynaptic Differentiation, Respectively" Fig.6: "Blockade of TrkC-PTPσ Interaction with a Neutralizing Antibody Inhibits Synaptogenic Activity of TrkC and PTPσ and Reduces Excitatory Synapse Density" The model is that presynaptic PTPσ clusters postsynaptic TrkC which in turn instructs postsynapse assembly. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2338 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |