| Annotated protein: | Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR). Gene symbol: PTPRF. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q64604 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRF |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse organization (GO:0099175) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Dunah AW, et al. "LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses" Nat Neurosci. 2005 Apr;8(4):458-67 PMID:15750591 |
| Figure(s): | Fig.2,3,4,5 |
| Annotation description: | Fig.2: "Overexpression of LAR interfering constructs reduces the number of excitatory synapses" Fig.3: "LAR interfering constructs decrease the density of dendritic spines" Fig.4: "RNAi knockdown of LAR-RPTP reduces the density of synapses and spines" Fig.5: "Effects of dominant-negative LAR constructs on synaptic function" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2335 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |