| Annotated protein: | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2). Gene symbol: LRFN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P0C7J6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRFN1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic density assembly (GO:0099151) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Ko J, et al. "SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses" Neuron. 2006 Apr 20;50(2):233-45 PMID:16630835 |
| Figure(s): | Fig.4, 5, 6, 7 |
| Annotation description: | Fig.4: "Overexpression of SALM2 Leads to Increases in the Number of Excitatory Synapses and Dendritic Spines" Fig.5: "Mislocalized Expression of SALM2 Disrupts Excitatory Synapses and Dendritic Spines" Fig.6: "Direct Aggregation of SALM2 Induces Clustering of Excitatory Postsynaptic Proteins" Fig.7: "Knockdown of SALM2 by siRNA Leads to the Loss of Morphological and Functional Excitatory Synapses" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2332 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |