Annotated protein:Leucine-rich repeat and fibronectin type-III domain-containing protein 4. Gene symbol: LRFN4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q80XU8
antibody wiki:
SynGO gene info:SynGO data @ LRFN4
Ontology domain:Biological Process
SynGO term:regulation of presynapse assembly (GO:1905606)
Synapse type(s):hippocampus, glutamatergic
hippocampus, GABAergic
Annotated paper:Mah W, et al. "Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation" J Neurosci. 2010 Apr 21;30(16):5559-68 PMID:20410109
Figure(s):Fig.1, 2, 3, 5, 6, 8
Annotation description:Fig.1: "SALM3 and SALM5 expressed in nonneural cells induce presynaptic differentiation in contacting axons"
Fig.2: "SALM3 and SALM5 induce excitatory and inhibitory presynaptic protein clustering"
Fig.3: "SALM3 and SALM5 induce the uptake of synaptotagmin lumenal domain antibodies in contacting axons of cocultured neurons"
Fig.5: "Overexpression of SALM3 and SALM5 in cultured neurons increases the amount of presynaptic contacts"
Fig.6: "Overexpression of SALM3 and SALM5 in cultured neurons increases the amount of excitatory and inhibitory presynaptic contacts"
Evidence tracking, Biological System:Cultured neurons
Non-neuronal tissue
Evidence tracking, Protein Targeting:RNAi / shRNA
Over-expression
Evidence tracking, Experiment Assay:Confocal
Whole-cell patch clamp
Annotator(s):Hwajin Jung (ORCID:0000-0001-6194-9648)
Eunjoon Kim (ORCID:0000-0001-5518-6584)
Lab:Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea
SynGO annotation ID:2330
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology