| Annotated protein: | Leucine-rich repeat and fibronectin type-III domain-containing protein 5. Gene symbol: LRFN5. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BXA0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRFN5 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of presynapse assembly (GO:1905606) |
| Synapse type(s): | hippocampus, glutamatergic hippocampus, GABAergic |
| Annotated paper: | Mah W, et al. "Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation" J Neurosci. 2010 Apr 21;30(16):5559-68 PMID:20410109 |
| Figure(s): | Fig.1, 2, 3, 5, 6, 8 |
| Annotation description: | Fig.1: "SALM3 and SALM5 expressed in nonneural cells induce presynaptic differentiation in contacting axons" Fig.2: "SALM3 and SALM5 induce excitatory and inhibitory presynaptic protein clustering" Fig.3: "SALM3 and SALM5 induce the uptake of synaptotagmin lumenal domain antibodies in contacting axons of cocultured neurons" Fig.5: "Overexpression of SALM3 and SALM5 in cultured neurons increases the amount of presynaptic contacts" Fig.6: "Overexpression of SALM3 and SALM5 in cultured neurons increases the amount of excitatory and inhibitory presynaptic contacts" Fig.8: "Knockdown of SALM5 decreases the number and function of both excitatory and inhibitory synapses" |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2329 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |