| Annotated protein: | Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3). Gene symbol: LRRC4B. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P0CC10 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRRC4B |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of presynapse assembly (GO:1905606) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Woo J, et al. "Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses" Nat Neurosci. 2009 Apr;12(4):428-37 PMID:19252495 |
| Figure(s): | Fig.1, 3, 5, 7 |
| Annotation description: | Fig.1: "NGL-3 expressed in non-neural cells induces functional presynaptic differentiation in contacting axons" Fig.3: "Overexpression of NGL-3 in cultured neurons increases excitatory, but not inhibitory, presynaptic contacts on dendrites of transfected neurons" Fig.5: "Knockdown of NGL-3 leads to decreases in the number and function of excitatory synapses" Fig.7: "Soluble LAR reduces NGL-3-induced presynaptic differentiation" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2327 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |