| Annotated protein: | Netrin-G2 (Laminet-2). Gene symbol: NTNG2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R4F1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NTNG2 |
| Ontology domain: | Cellular Component |
| SynGO term: | anchored component of presynaptic active zone membrane (GO:0099029) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Matsukawa H, et al. "Netrin-G/NGL complexes encode functional synaptic diversification" J Neurosci. 2014 Nov 19;34(47):15779-92 PMID:25411505 |
| Figure(s): | fig 1D, F |
| Annotation description: | Immunoparticles for Netrin-G1 were mostly detected in the presynaptic active zone membrane of dendritic spines in SR. 2/1/2018 Pim - Literal: "Excitatory asymmetric synapses immunolabeled with netrin-G1 and netrin-G2 antibodies were detected in the SLM and SR, respectively (Fig. 1D)"...."Netrin-G1 and netrin-G2 immunoparticles had peak radial distances within the first external bin from the presynaptic membrane (i.e., within the synaptic cleft)" ... "These findings indicate that netrin-Gs are presynaptic proteins and NGLs are postsynaptic proteins." Note: 'SR' means 'CA1 stratum radiatum' - Based on the known lipid anchor of the protein, the "anchored component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2322 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |