| Annotated protein: | Cadherin 13 (T-cadherin). Gene symbol: CDH13. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q8R490 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CDH13 |
| Ontology domain: | Cellular Component |
| SynGO term: | synapse (GO:0045202) |
| Synapse type(s): | hippocampus, GABAergic |
| Annotated paper: | Rivero O, et al. "Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition" Transl Psychiatry. 2015 Oct 13;5(10):e655 PMID:26460479 |
| Figure(s): | Fig. 2 |
| Annotation description: | Results Section: "CDH13 is located at inhibitory synapses" -Literal: "To determine the specific synaptic localization of endogenous CDH13, we co-stained hippocampal neurons at 14 days in vitro for CDH13 and the presynaptic markers vesicular glutamate transporter (VGLUT) or vesicular GABA transporter (VGAT) (excitatory and inhibitory, respectively) or the postsynaptic markers PSD95 or gephyrin (excitatory and inhibitory, respectively; Figure 2b). CDH13 colocalized exactly with the presynaptic marker VGAT, but not VGLUT. At the postsynaptic side, CDH13 showed juxtaposed labeling with gephyrin, but not with PSD95." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 2320 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |