| Annotated protein: | Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin). Gene symbol: CDH11. Taxonomy: Mus musculus (Mouse). Uniprot ID: P55288 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CDH11 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Manabe T, et al. "Loss of cadherin-11 adhesion receptor enhances plastic changes in hippocampal synapses and modifies behavioral responses" Mol Cell Neurosci. 2000 Jun;15(6):534-46 PMID:10860580 |
| Figure(s): | Fig. 5C |
| Annotation description: | Results Section: "LTP Is Enhanced in Cad11-Deficient Hippocampus" -Literal: "Unexpectedly, however, the LTP induced by a train of tetanic stimulation (100 Hz, 1 s) was significantly larger (P 5 0.0054) in the mutant mice (162.1 6 5.6% of control, n 5 8) than in the wild-type mice (134.6 6 6.1% of control, n 5 7)" 15/01/2018 Pim - Preferably annotation to the primary function of CDH11 would be made (cell adhesion). Since this paper does not demonstrate that this role is mediating the effect of CDH11 in regulating LTP I approve of the use of the term 'modulation of chemical synaptic transmission (GO:0050804)' to describe the effect on LTP. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) none of the above |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 2319 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |