| Annotated protein: | Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin). Gene symbol: CDH11. Taxonomy: Mus musculus (Mouse). Uniprot ID: P55288 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CDH11 |
| Ontology domain: | Cellular Component |
| SynGO term: | synapse (GO:0045202) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Manabe T, et al. "Loss of cadherin-11 adhesion receptor enhances plastic changes in hippocampal synapses and modifies behavioral responses" Mol Cell Neurosci. 2000 Jun;15(6):534-46 PMID:10860580 |
| Figure(s): | Fig. 3A/B |
| Annotation description: | Fig. 3 Legend: -Literal "Double-immunofluorescence staining for cad11 and synaptophysin or GluR1 in cultured hippocampal neurons. (A) Double-staining for cad11 (green) and synaptophysin (red). (B) Double-staining for cad11 (green) and GluR1 (red). Insets show enlargement of the portions enclosed with rectangles. mAb 2F9D9 was used for the cad11 staining. Arrowheads point to examples of sites in which the two color signals overlapped." Discussion: -Literal: "This study demonstrated that cad11 proteins were densely distributed in synaptic zones of the hippocampus, and their distribution overlapped with that of synaptophysin and GluR1 in cultured hippocampal neurons, suggesting that they were associated with at least a certain population of synapse." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 2318 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |