| Annotated protein: | Cadherin 10. Gene symbol: CDH10. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: F1LR98 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CDH10 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | neocortex, glutamatergic neocortex, GABAergic |
| Annotated paper: | Smith KR, et al. "Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins" J Neurosci. 2017 Nov 15;37(46):11127-11139 PMID:29030434 |
| Figure(s): | Fig. 2A/B |
| Annotation description: | Results: "Cadherin-10 is localized to excitatory and inhibitory pre- and post-synaptic sites" - Literal "To assess pre- vs. post-synaptic location of cadherin-10, we performed immunogold-EM, which showed cadherin-10 labeling was both at the presynaptic active zone and the PSD of excitatory synapses (Fig. 2A). Double labeling for the inhibitory neurotransmitter GABA revealed that cadherin-10 gold particles were also present pre- and postsynaptically at inhibitory synapses" 30/12/2017 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 2316 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |