| Annotated protein: | F-actin-capping protein subunit beta (CapZ beta). Gene symbol: CAPZB. Taxonomy: Mus musculus (Mouse). Uniprot ID: P47757-2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CAPZB |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Kitanishi T, et al. "Activity-dependent localization in spines of the F-actin capping protein CapZ screened in a rat model of dementia" Genes Cells. 2010 Jun;15(7):737-47 PMID:20545768 |
| Figure(s): | Fig.3 |
| Annotation description: | Fig.3A: "A punctate and discrete CapZ signal was found in the spines of CA1 pyramidal and dentate granule cells (Fig. 3A, N = 4 cells each from four mice from three independent experiments for CA1 apical, CA1 basal and dentate apical dendrites)." Fig. 3C. "CapZ beta 2 was often detected at the postsynaptic density (arrows) and was also found in the extrasynaptic plasma membrane and cytosol (arrowheads) of dendritic spines" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 2315 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |