Annotated protein:Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2). Gene symbol: PTPRO. Taxonomy: Mus musculus (Mouse). Uniprot ID: E9Q612
antibody wiki:
SynGO gene info:SynGO data @ PTPRO
Ontology domain:Cellular Component
SynGO term:integral component of postsynaptic density membrane (GO:0099061)
Annotated paper:Jiang W, et al. "Identification of Protein Tyrosine Phosphatase Receptor Type O (PTPRO) as a Synaptic Adhesion Molecule that Promotes Synapse Formation" J Neurosci. 2017 Oct 11;37(41):9828-9843 PMID:28871037
Figure(s):fig 3F-3H
Annotation description:PTPRO was enriched in postsynaptic density fractions.
PTPRO colocalized with PSD-95, confirming the postsynaptic localization.

26/01/2018 Pim
- Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:Intact tissue
Cultured neurons
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Confocal
Western blot
Biochemical fractionation (generic)
Annotator(s):Hwajin Jung (ORCID:0000-0001-6194-9648)
Eunjoon Kim (ORCID:0000-0001-5518-6584)
Lab:Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea
SynGO annotation ID:2311
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology