| Annotated protein: | protein-tyrosine-phosphatase (EC 3.1.3.48). Gene symbol: PTPRT. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: F1LXJ9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRT |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lim SH, et al. "Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn" EMBO J. 2009 Nov 18;28(22):3564-78 PMID:19816407 |
| Figure(s): | fig 1E, fig 1K-1N |
| Annotation description: | PTPRT was enriched in postsynaptic density fractions. PTPRT co-localized to neuronal synapses stained with synaptophysin and PSD-95. PTPRT co-localized to excitatory synapses with PSD-95 and vGLUT or to inhibitory synapses with gephyrin and vGAT. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2310 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |