| Annotated protein: | Calbindin (Calbindin D28) (D-28K) (PCD-29) (Spot 35 protein) (Vitamin D-dependent calcium-binding protein, avian-type). Gene symbol: CALB1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P12658 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CALB1 |
| Ontology domain: | Biological Process |
| SynGO term: | calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels (GO:0099567) |
| Synapse type(s): | cerebellum, glutamatergic |
| Annotated paper: | Airaksinen MS, et al. "Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene" Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1488-93 PMID:9037080 |
| Figure(s): | Figure 4 |
| Annotation description: | This paper utilizes the Calbindin knockout mouse and directly addresses it role in Ca2+ binding and buffering. Using Calcium Green-1 fluorescence it establishes that calbindin deficient Purkinje cell dendrites have an elevated Ca2+ in response to climbing fibre synaptic inputs. The somatic resting levels of Ca2+ remain unchanged in the wild type showing a selective role to synaptic Ca2+ buffering. 24/01/2018 Pim - Calbindin is a known Ca2+-binding protein that has 5 EF-hands. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Optical physiology |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 2289 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |