| Annotated protein: | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3). Gene symbol: RELA. Taxonomy: Homo sapiens (Human). Uniprot ID: Q04206 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RELA |
| Ontology domain: | Biological Process |
| SynGO term: | postsynapse to nucleus signaling pathway (GO:0099527) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Meffert MK, et al. "NF-kappa B functions in synaptic signaling and behavior" Nat Neurosci. 2003 Oct;6(10):1072-8 PMID:12947408 |
| Figure(s): | Fig 2 |
| Annotation description: | Over expression of EGFP-p65 allowed the investigation of the protein redistribution from the dendritic brunch to the nucleus using a FRAP approach. Following photobleaching of a dendritic segment, authors observed fluorescence recovery which was unidirectional and triggered only by NMDA application. Accordingly, photobleaching of the somatic region shows a significant recovery after NMDA application, different from the recovery observed under basal conditions. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Fluorescence recovery after photobleaching (FRAP) |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 2275 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |