| Annotated protein: | Proline-rich protein 7 (Synaptic proline-rich membrane protein). Gene symbol: PRR7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P0C6T3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PRR7 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynapse to nucleus signaling pathway (GO:0099527) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Kravchick DO, et al. "Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity" EMBO J. 2016 Sep 1;35(17):1923-34 PMID:27458189 |
| Figure(s): | Fig 2 |
| Annotation description: | Experiments in primary hippocampal cultures show that immunolabeling of endogenous Prr7 is enhanced in the nucleus after glutamate treatment while its synaptic localization is decreased. FRAP experiments confirmed the redistribution of the protein to the nucleus after glutamate application by using overexpression of Prr7-GFP. Use of photoconvertible Prr7-mEos3 further confirmed this. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Fluorescence recovery after photobleaching (FRAP) |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 2270 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |