| Annotated protein: | Proline-rich protein 7 (Synaptic proline-rich membrane protein). Gene symbol: PRR7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P0C6T3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PRR7 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density, intracellular component (GO:0099092) |
| Synapse type(s): | hippocampus, glutamatergic neocortex, glutamatergic |
| Annotated paper: | Murata Y, et al. "Proteomic analysis revealed a novel synaptic proline-rich membrane protein (PRR7) associated with PSD-95 and NMDA receptor" Biochem Biophys Res Commun. 2005 Feb 4;327(1):183-91 PMID:15629447 |
| Figure(s): | Fig 2,3,4,5,6. |
| Annotation description: | Authors identified Prr7 in a proteomic study of the PSD fraction and developed a polyclonal antibody against it. They found that Prr7 is enriched in PSD fractions of the hippocampus and cerebral cortex. Purified Prr7 immunoprecipitated NR2B, NR1 and PSD-95 and pull-down assay shows direct interaction between Prr7 and PSD-95. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) IP + WB/MSMS |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 2265 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |