| Annotated protein: | ubiquitinyl hydrolase 1 (EC 3.4.19.12). Gene symbol: USP8. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZN39 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ USP8 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of protein catabolic process at postsynapse, modulating synaptic transmission (GO:0099576) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Scudder SL, et al. "Synaptic strength is bidirectionally controlled by opposing activity-dependent regulation of Nedd4-1 and USP8" J Neurosci. 2014 Dec 10;34(50):16637-49 PMID:25505317 |
| Figure(s): | Fig.3-6 |
| Annotation description: | Background: USP8 is a known deubiquitinase. Fig.3: "Rapid NMDAR-dependent dephosphorylation and activation USP8" Deubiquitinating enzyme USP8 is activated by NMDAR activation. Fig.4: "USP8 regulates synaptic strength" Deubiquitinating enzyme USP8 deubiquitinates AMPARs and regulates synaptic strength. Fig.5: "Synaptic activity levels regulate Nedd4-1 and USP8 in opposing fashion" Fig.6: "Nedd4-1 and USP8 are regulators of homeostatic downscaling" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp Western blot |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 2263 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |