| Annotated protein: | Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2). Gene symbol: GABRB2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P63137 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRB2 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | cerebellum, GABAergic |
| Annotated paper: | He Q, et al. "Interneuron- and GABA(A) receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells" Nat Commun. 2015 Jul 16;6:7364 PMID:26179122 |
| Figure(s): | Fig.5 |
| Annotation description: | Background: GABA-ergic transmission between cerebellar interneuron and Purkinje cell (PC) is examined. This synapse is plastic and increases in strength after presynaptic stimulation, critically relies on an increase in number of postsynaptic GABAA receptors containing the β2-subunit. Fig.5: "β2-subunit dependence of RP" - "The mIPSC amplitude distributions revealed a significant reduction in the large-amplitude IPSCs in β2-/- slices..." - "We therefore conclude that BC-PC synapses contain a single population of GABAA receptors that include the β2-subunit" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | PMID:26592470 |
| SynGO annotation ID: | 2253 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |