| Annotated protein: | Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2). Gene symbol: GABRB2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P63137 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRB2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | thalamus, GABAergic |
| Annotated paper: | Seo S, et al. "Synaptic changes in GABAA receptor expression in the thalamus of the stargazer mouse model of absence epilepsy" Neuroscience. 2015 Oct 15;306:28-38 PMID:26297893 |
| Figure(s): | Fig.2 |
| Annotation description: | Fig.2: "Immunogold analysis of GABAAR α1 and β2 subunit at VP inhibitory synapses in control and stargazer mice." - "Likewise, the average density of gold label for the β2 subunit per μm PSD length was 6.40 ± 0.24 for controls and 9.33 ± 0.37 for the stargazer mice, representing a 45.7% increase (Fig. 2D)' - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2252 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |