| Annotated protein: | Cortactin-binding protein 2 (CortBP2). Gene symbol: CTTNBP2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q2IBD4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CTTNBP2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of modification of postsynaptic actin cytoskeleton (GO:1905274) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Chen YK, et al. "Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance" J Neurosci. 2012 Jan 18;32(3):1043-55 PMID:22262902 |
| Figure(s): | Figure 4, 5, 7, Table 1 |
| Annotation description: | CTTNBP2 regulates dendritic spine morphology and synaptic activity (Fig 4) by stabilizing the actin actin-binding protein cortactin (CTTN; SynGO ID 223) at synapses (Fig 5 and 7). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Fluorescence recovery after photobleaching (FRAP) Whole-cell patch clamp IP + WB/MSMS |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 225 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |