| Annotated protein: | Protein TANC1 (TPR domain, ankyrin-repeat and coiled-coil domain-containing protein 1). Gene symbol: TANC1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q6F6B3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TANC1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density, intracellular component (GO:0099092) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Han S, et al. "Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins" J Neurosci. 2010 Nov 10;30(45):15102-12 PMID:21068316 |
| Figure(s): | Fig.1, 2G |
| Annotation description: | TANC1 was enriched in postsynaptic density fractions. 26/01/2018 Pim - TANC1 interacts and colocalizes with PSD-95. - EM data in Fig.5 is made with a pan-TANC antibody that is not gene paralog specific. This data is excluded from the referenced figures. |
| Evidence tracking, Biological System: | Intact tissue Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Biochemical fractionation (generic) IP + WB/MSMS Y2H |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2249 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |